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October 05, 2019
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Sean F. Monaghan, MD, FACS

Associate Professor of Surgery, Vice Chair of Research - Warren Alpert Medical School at Brown University

(401) 228-0564

Accepting New Patients

Specialties

Board Certification: American Board of Surgery (General Surgery, Surgical Critical Care)

Education: University of Medicine and Dentistry of New Jersey, Newark, NJ

Residency: General Surgery - Rhode Island Hospital, Warren Alpert Medical School at Brown University, Providence, RI

Fellowship: Surgical Critical Care - Beth Israel Deaconess Medical Center, Boston, MA

Memberships in Societies:
Fellow - American College of Surgeons (FACS)
American Association for the Surgery of Trauma
Association of Academic Surgery
Surgical Infection Society
Shock Society

Hospital Affiliations: Rhode Island Hospital

In the News

Research & Publications

  1. Deitch, EA, Livingston, DH, Lavery, RF, Monaghan, SF, Bongu, A, Macheido, GW. Hormonally Active Females Tolerate Shock Better Than Males: A Prospective Study of Over 4000 Trauma Patients. Annals of Surgery, 2007; 246 (3), 447-53. (PMID 17717448)
  2. Monaghan, SF, Anjaria, D, Mohr, A, Livingston DH. Necrotizing Fasciitis and Sepsis Caused by Aeromonas hydrophila after Crush Injury of the Lower Extremity. Surgical Infections, 2008; 9(4), 459-67. (PMID 18687029)
  3. Monaghan, SF and Swan, KE. Tube Thoracostomy: The Struggle to the “standard of care.” Annals of Thoracic Surgery, 2008; 86(6), 2019-22. (PMID 19022041)
  4. Heffernan, DS, Thakkar, RK, Monaghan, SF, Ravindran, R, Adams, CA, Kozloff, MS, Gregg, SC, Connolly, MD, Machan, JT, Cioffi, WG. Normal Presenting Vital Signs are Unreliable in Geriatric Blunt Trauma Victims. Journal of Trauma, 2010; 69(4):813-820. (PMID 20938267)
  5. Thakkar, RK, Chung, CS, Chen, Y, Monaghan, SF, Lomas-Neira J, Heffernan, DS, Cioffi, WG, Ayala, A. Local Tissue Expression of the Cell Death Ligand, Fas Ligand, Plays a Central Role in the Development of Extra-Pulmonary Acute Lung Injury.  Shock, 2011; 36(2), 138-143. (PMID 21451443)
  6. Heffernan, DS, Vera, RM, Monaghan, SF, Thakkar, RK, Kozloff, MS, Connolly, MD, Gregg, SC, Harrington, DT, Adams, CA, Cioffi, WG. The Impact of Socioethnic Factors on Outcomes Following Traumatic Brain Injury. Journal of Trauma, 2011; 70(3): 527-534. (PMID 21610339)
  7. Shubin, NJ, Monaghan, SF, Ayala, A. Anti-inflammatory Mechanisms of Sepsis. Contributions to Microbiology, 2011, 17:108-124. (PMID 21659749)
  8. Monaghan, SF, Heffernan, DS, Thakkar, RK, Machan, JT, Reinert, SE, Connolly, MD, Gregg, SC, Kozloff, MS, Adams, CA, Cioffi, WG. The Development of a Urinary Tract Infection is Associated with Increased Mortality in Trauma Patients. Journal of Trauma, 2011; 71(6): 1569-74. (PMID 21768897)
  9. Monaghan, SF, Thakkar, RK, Heffernan DS, Huang, X, Chung, CS, Lomas-Neira, J, Cioffi, WG, Ayala, A. Mechanisms of Indirect Acute Lung Injury: A Novel Role for the Co-Inhibitory Receptor, Programmed Death-1 (PD-1). Annals of Surgery, 2012; 255(1):158-164. (PMID 21997806)
  10. Heffernan, DS, Monaghan, SF, Thakkar, RK, Machan, JT, Cioffi, WG, Ayala, A. Failure to Normalize Lymphopenia Following Trauma is Associated with Increased Mortality, Independent of the Leukocyte Pattern. Critical Care, 2012; 16(1):R12. (PMID 22264310)
  11. Shubin, NJ, Chung, CS, Heffernan, DS, Irwin, L, Monaghan, SF, Ayala, A. BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction. Journal of Leukocyte Biology, 2012, 92(3), 593-603. (PMID 22459947)
  12. Monaghan, SF, Thakkar, RK, Tran, M, Huang, X, Cioffi, WG, Ayala, A, Heffernan, DS. PD-1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient. Shock, 2012; 38(2), 117-22. (PMID 22683728)
  13. Monaghan, S.F., Blakely, A.M., Richardson, P.J., Miner, T.J., Cioffi, W.G., Harrington, D.T. The reflective statement: A new tool to assess resident learning. Journal of Surgical Research, 2012, 178(2), 1079-85. (PMID: 22883435)
  14. Monaghan, S.F., Adams, C.A., Stephen, A.H., Connolly, M.D., Gregg, S.C., Machan, J.T., Cioffi, W.G., Heffernan, D.S., Infections after trauma are associated with subsequent cardiac injury. Journal of Trauma and Acute Care Surgery, 2012; 73(5): 1079-85 (PMID 23117374)
  15. Duron, V., Monaghan, S.F., Connolly, M.D., Gregg, S.C., Stephen, A.H., Adams, C.A., Cioffi, W.G., Heffernan, D.S. Undiagnosed medical co-morbidities in the uninsured: A significant predictor of mortality following trauma. Journal of Trauma and Acute Care Surgery, 2012; 73(5): 1093-99 (PMID 23117376)
  16. Thakkar, R.K., Monaghan, S.F., Adams, CA, Stephen, A., Connolly, MD, Gregg, S, Cioffi, W.G., Heffernan, D.S. Empiric antibiotics pending bronchial alveolar lavage data in patients without pneumonia significantly alters the flora, but not the resistance profile, if a subsequent pneumonia develops. Journal of Surgical Research, 2013, 181(2), 323-28. (PMID:22906560)
  17. Heffernan, D.S., Monaghan, S.F., Thakkar, R.K., Tran, M.L., Chung, C.S., Gregory, S.H., Cioffi, W.G., Ayala, A. Inflammatory Mechanisms in Sepsis: Elevated Invariant Natural Killer T-Cell Numbers in Mouse and Their Modulatory Effect on Macrophage Function. Shock, 2013; 40(2), 122-128. (PMID 23807244)
  18. Shubin, N.J., Monaghan, S.F., Heffernan, D.S., Chung, C.S., Ayala, A. B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients. Critical Care, 2013; 17(6). (PMID 24289156)
  19. Heffernan, D.S., Monaghan, S.F., Chung, C.S., Cioffi, W.G., Gravenstein, S., Ayala, A. A divergent response of innate regulatory T-cells to sepsis in humans: Circulating invariant natural killer T-cells are preserved. Human Immunology, 2014, 75(3), 277-282. (PMID 24269692)
  20. Huang, X., Chen, Y., Chung, C.S., Yuan, Z., Monaghan, S.F., Wang, F., Ayala, A. Identification of B7-H1 as a Novel Mediator of the Innate Immune/Proinflammatory Response as well as a Possible Myeloid Cell Prognostic Biomarker in Sepsis. Journal of Immunology, 2014, 192(3), 1091-99. (PMID 24379123)
  21. Ottinger, M.E., Monaghan, S.F., Gravenstein, S., Cioffi, W.G., Ayala, A., Heffernan, D.S. The Geriatric Cytokine Response to Trauma: Time to Consider a New Threshold. Surgical Infections, 2014, 15(6), 800-05. (PMID 25494395)
  22. Young, J.S., Monaghan, S.F., Chung, C.S., Cioffi, W.G., Ayala, A., Heffernan, D.S., Divergent Invariant Natural Killer T-Cell Response to Sepsis of Abdominal vs. Non-Abdominal Origin in Human Beings. Surgical Infections, 2015, 16 (1), 29-35. (PMID 25761007)
  23. Lomas-Neir, J.L., Heffernan, D.S., Ayala, A., Monaghan, S.F. Blockade of endothelial growth factor, angiopoietin-2, reduces indices of ARDS and mortality in mice resulting from the dual-insult of hemorrhagic shock and sepsis. Shock, 2016, 45(2), 157-165. (PMID 26529660)
  24. Zimmerman, A.M., Marwaha, J., Nunez, H., Harrington, D., Heffernan, D., Monaghan, S., Adams, C., Stephen, A. Preoperative Myocardial Injury as a Predictor of Mortality in Emergency General Surgery: An Analysis Using the American College of Surgeons NSQIP Database. Journal of the American College of Surgeons, 2016, 223(2), 381-386. (PMID 27163647)
  25. Wu Y., Chung C.S., Chen Y., Monaghan S.F., Patel S., Huang X., Heffernan D.S., Ayala A. A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction. Molecular medicine (Cambridge, Mass). 2016, 22. Epub 2016/10/27. (PMID: 27782294)
  26. Monaghan S.F., Chung C.S., Chen Y., Lomas-Neira J., Fairbrother W.G., Heffernan D.S., Cioffi W.G., Ayala A. Soluble Programmed Cell Death Receptor-1 (sPD-1): A Potential Biomarker with Anti-inflammatory Properties in Human and Experimental Acute Respiratory Distress Syndrome (ARDS). Journal of Translational Medicine. 2016 (PMID 27835962)
  27. Kao, M.J., Nunez, H., Monaghan, S.F., Heffernan, D.S., Adams, C.A., Lueckel, S.N., Stephen, A.H. Trauma Patients Who Present in a Delayed Fashion: A Unique and Challenging Population. Journal of Surgical Research. 2017, Feb 208:204-210. (PMID 27993211)
  28. Ottinger M.E., Monaghan S.F., Gregg S.C., Stephen A.H., Connolly M.D., Harrington D.T., Adams C.A. Jr, Cioffi W.G., Heffernan D.S. Trauma morning report is the ideal environment to teach and evaluate resident communication and sign-outs in the 80 hour work week. Injury. 2017 May 1(PubMed PMID: 28506455.)
  29. Dickinson C.M., Karlin D.R., Nunez H.R., Cao S.A., Heffernan D.S., Monaghan S.F., Kheirbek T., Adams C.A., Stephen A.H. Do Patients with Pre-Existing Psychiatric Illness Have an Increased Risk of Infection after Injury? Surg Infect (Larchmt). 2017 Jul;18(5):545-549 (PMID: 28353417.)
  30. Heffernan D.S., Monaghan S.F., Ayala A. Lymphocyte integrin expression differences between SIRS and sepsis patients. Irish Journal of Medical Science. 2017. Nov 186(4) 981-987. (PMID: 27796667)
  31. Fallon E.A., Biron-Girard B.M., Chung C.S., Lomas-Neira J., Heffernan D.S., Monaghan S.F., Ayala A. A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis. J Leukoc Biol. 2018 Feb 2. (PMID: 29393983.)
  32. Rhine C.L., Cygan K.J., Soemedi R., Maguire S., Murray M.F., Monaghan S.F., Fairbrother W.G. Hereditary cancer genes are highly susceptible to splicing mutations. PLoS Genet. 2018 Mar 5;14 (PMID: 29505604.)
  33. Lueckel, S.N., Kosar, C.M., Teno, J.M., Monaghan, S.F., Heffernan, D.S., Cioffi, W.G., Thomas, K.S. Outcomes in nursing home patients with traumatic brain injury. Surgery. 2018 May 9 (PMID: 29751966)
  34. Banerjee, D., Monaghan, S., Zhai, R., Walsh, R., Palmisciano, A., Phillips, G.S., Opal, S., Levy, M.M. Soluble programmed cell death protein-1 and programmed cell death ligand-1 in sepsis. Crit Care. 2018 June 7; 22(1): 146 (PMID 29875013)
  35. Monaghan, S.F., Banerjee, D., Chung, C.S., Lomas-Neira, J., Cygan, K.J., Rhine, C.L., Fairbrother, W.G., Heffernan, D.S., Levy, M.M., Cioffi, W.G., Ayala, A. Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Molecular Medicine. 2018, 24:32 (PMID 30134817)
  36. Stephen, AH, Shah, M, Sim, JT, Soipe, A, Lueckel, SN, Kheirbek, T, Heffernan, DS, Monaghan, SF, Adams, CA, Jr. Dismal outcomes following damage control laparotomy in injured older adults: a cohort study. Am J Surg. Nov 14. (PMID 30502874)
  37. Lomas-Neira, J.L., Monaghan, S.F., Huang, X., Fallon, E.A., Chung, C.S., Ayala, A. Novel role for PD-1: PD-L 1 as mediator of neutrophil: endothelial interactions in pathogenesis of indirect ARDS in mice. Front. lmmunol. 2018 Dec 20:9 (PMID 30619639)

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